Time‐Course of Arm Lymphedema and Potential Risk Factors for Progression of Lymphedema After Breast Conservation Treatment for Early Stage Breast Cancer
Identifieur interne : 004643 ( Main/Exploration ); précédent : 004642; suivant : 004644Time‐Course of Arm Lymphedema and Potential Risk Factors for Progression of Lymphedema After Breast Conservation Treatment for Early Stage Breast Cancer
Auteurs : Voichita Bar Ad [États-Unis] ; Pinaki R. Dutta [États-Unis] ; Lawrence J. Solin [États-Unis] ; Wei-Ting Hwang [États-Unis] ; Kay See Tan [États-Unis] ; Stefan Both [États-Unis] ; Andrea Cheville [États-Unis] ; Eleanor E. R. Harris [États-Unis]Source :
- The Breast Journal [ 1075-122X ] ; 2012-05.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Aisselle (anatomopathologie), Aisselle (effets des radiations), Analyse multivariée, Bras (), Bras (anatomopathologie), Facteurs de l'âge, Facteurs de risque, Femelle, Humains, Lymphadénectomie (effets indésirables), Lymphoedème (étiologie), Mastectomie partielle, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein (), Tumeurs du sein (radiothérapie), Études de suivi, Études rétrospectives, Évolution de la maladie.
- MESH :
- anatomopathologie : Aisselle, Bras.
- effets des radiations : Aisselle.
- effets indésirables : Lymphadénectomie.
- radiothérapie : Tumeurs du sein.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Analyse multivariée, Bras, Facteurs de l'âge, Facteurs de risque, Femelle, Humains, Mastectomie partielle, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein, Études de suivi, Études rétrospectives, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Arm (pathology), Arm (surgery), Axilla (pathology), Axilla (radiation effects), Breast Neoplasms (complications), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Breast Neoplasms (therapy), Disease Progression, Female, Follow-Up Studies, Humans, Lymph Node Excision (adverse effects), Lymphedema (etiology), Mastectomy, Segmental, Middle Aged, Multivariate Analysis, Retrospective Studies, Risk Factors.
- MESH :
- adverse effects : Lymph Node Excision.
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- pathology : Arm, Axilla.
- radiation effects : Axilla.
- radiotherapy : Breast Neoplasms.
- surgery : Arm, Breast Neoplasms.
- therapy : Breast Neoplasms.
- Adult, Age Factors, Aged, Aged, 80 and over, Disease Progression, Female, Follow-Up Studies, Humans, Mastectomy, Segmental, Middle Aged, Multivariate Analysis, Retrospective Studies, Risk Factors.
Abstract
Abstract: The objective of this study was to describe the progression of arm lymphedema (ALE) after the initial presentation among patients receiving breast conservation therapy for early stage breast cancer and to identify potential risk factors contributing to ALE progression. The study sample was the 266 stage I or II breast cancer patients with documented ALE who underwent breast conservation therapy that included lumpectomy, axillary staging followed by radiation therapy. ALE were graded according to a difference of 0.5–2 cm (mild), 2.1–3 cm (moderate), and >3 cm (severe) in the circumference between the upper extremities for the treated and untreated sides. ALE at presentation was scored as mild, moderate, and severe in 109 (41%), 125 (47%), and 32 (12%) patients, respectively. One third of patients with ALE progressed to a more severe grade of lymphedema at 5 years of follow‐up. Age older than 65 years at the time of breast cancer treatment was associated with higher risk of ALE progression when compared 65 year age or younger (p = 0.04). The patients who had regional lymph node irradiation including posterior axillary boost were at higher risk of lymphedema progression than the patients treated with whole breast irradiation only (p = 0.001). Progression of ALE is a common occurrence. The current study provides support for the utility of routine arm measurements after breast cancer treatment to facilitate timely diagnosis and treatment of ALE.
Url:
DOI: 10.1111/j.1524-4741.2012.01229.x
Affiliations:
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radiations)</term><term>Analyse multivariée</term><term>Bras ()</term><term>Bras (anatomopathologie)</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Lymphadénectomie (effets indésirables)</term><term>Lymphoedème (étiologie)</term><term>Mastectomie partielle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (radiothérapie)</term><term>Études de suivi</term><term>Études rétrospectives</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Aisselle</term><term>Bras</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Aisselle</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Lymphadénectomie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Arm</term><term>Axilla</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Axilla</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Arm</term><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Mastectomy, Segmental</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Retrospective Studies</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse multivariée</term><term>Bras</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mastectomie partielle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein</term><term>Études de suivi</term><term>Études rétrospectives</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Abstract: The objective of this study was to describe the progression of arm lymphedema (ALE) after the initial presentation among patients receiving breast conservation therapy for early stage breast cancer and to identify potential risk factors contributing to ALE progression. The study sample was the 266 stage I or II breast cancer patients with documented ALE who underwent breast conservation therapy that included lumpectomy, axillary staging followed by radiation therapy. ALE were graded according to a difference of 0.5–2 cm (mild), 2.1–3 cm (moderate), and >3 cm (severe) in the circumference between the upper extremities for the treated and untreated sides. ALE at presentation was scored as mild, moderate, and severe in 109 (41%), 125 (47%), and 32 (12%) patients, respectively. One third of patients with ALE progressed to a more severe grade of lymphedema at 5 years of follow‐up. Age older than 65 years at the time of breast cancer treatment was associated with higher risk of ALE progression when compared 65 year age or younger (p = 0.04). The patients who had regional lymph node irradiation including posterior axillary boost were at higher risk of lymphedema progression than the patients treated with whole breast irradiation only (p = 0.001). Progression of ALE is a common occurrence. The current study provides support for the utility of routine arm measurements after breast cancer treatment to facilitate timely diagnosis and treatment of ALE.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Bar Ad, Voichita" sort="Bar Ad, Voichita" uniqKey="Bar Ad V" first="Voichita" last="Bar Ad">Voichita Bar Ad</name></region><name sortKey="Both, Stefan" sort="Both, Stefan" uniqKey="Both S" first="Stefan" last="Both">Stefan Both</name><name sortKey="Cheville, Andrea" sort="Cheville, Andrea" uniqKey="Cheville A" first="Andrea" last="Cheville">Andrea Cheville</name><name sortKey="Dutta, Pinaki R" sort="Dutta, Pinaki R" uniqKey="Dutta P" first="Pinaki R." last="Dutta">Pinaki R. Dutta</name><name sortKey="Harris, Eleanor E R" sort="Harris, Eleanor E R" uniqKey="Harris E" first="Eleanor E. R." last="Harris">Eleanor E. R. Harris</name><name sortKey="Hwang, Wei Ing" sort="Hwang, Wei Ing" uniqKey="Hwang W" first="Wei-Ting" last="Hwang">Wei-Ting Hwang</name><name sortKey="Solin, Lawrence J" sort="Solin, Lawrence J" uniqKey="Solin L" first="Lawrence J." last="Solin">Lawrence J. Solin</name><name sortKey="Tan, Kay See" sort="Tan, Kay See" uniqKey="Tan K" first="Kay See" last="Tan">Kay See Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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